Drug interactions
Deferiprone + Mebendazole
Severity: Major
Deferiprone and Mebendazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause neutropenia or agranulocytosis, so combined use may increase the risk of serious myelosuppression. Deferiprone-induced agranulocytosis can be life-threatening.
What this interaction means in plain words
Deferiprone and Mebendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Mebendazole belongs to Anti Parasitic.
Why it happens
Additive bone marrow suppressive toxicity (pharmacodynamic).
What to do
Avoid the combination when an alternative anthelmintic exists. If used, monitor absolute neutrophil count more often and stop deferiprone for neutropenia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mebendazole
- Mebendazole + Metronidazole Major
- Acalabrutinib + Mebendazole Moderate
- Carbamazepine + Mebendazole Moderate
- Ethotoin + Mebendazole Moderate
- Fosphenytoin + Mebendazole Moderate
- Mebendazole + Phenytoin Moderate
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Mebendazole?
MediHelp rates the interaction as major. Deferiprone and Mebendazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause neutropenia or agranulocytosis, so combined use may increase the risk of serious myelosuppression. Deferiprone-induced agranulocytosis can be life-threatening.
How serious is the interaction between Deferiprone and Mebendazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when an alternative anthelmintic exists. If used, monitor absolute neutrophil count more often and stop deferiprone for neutropenia.
What other medicines interact with Mebendazole?
MediHelp also lists interactions of Mebendazole with, for example, Metronidazole, Acalabrutinib, Carbamazepine. The full list is on the Mebendazole page.
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