Drug interactions
mebendazole + metronidazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Signal for SJS/TEN with concomitant use.
Mechanism of action
Idiosyncratic dermatologic toxicity (non-PK).
Clinical management
Avoid concomitant use where possible; counsel for rash/fever and stop if symptoms.
Drug reference
References
- Mebendazole monograph — Drugs.com Pro
- Metronidazole + mebendazole SJS/TEN — PubMed
Frequently asked questions
Can I take mebendazole with metronidazole?
The interaction is rated: Major. Signal for SJS/TEN with concomitant use.
How serious is the interaction between mebendazole and metronidazole?
The interaction is rated: Major. Evidence level: Low.
How is the interaction between mebendazole and metronidazole managed?
Avoid concomitant use where possible; counsel for rash/fever and stop if symptoms.
Why do mebendazole and metronidazole interact?
Idiosyncratic dermatologic toxicity (non-PK).
Full monographs, dosing and an interaction checker in the MediHelp app
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