Drug interactions
Carbamazepine + Mebendazole
Severity: Moderate
Carbamazepine and Mebendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower mebendazole concentrations, which may reduce anthelmintic effectiveness, particularly in systemic infections such as hydatid disease.
What this interaction means in plain words
Carbamazepine and Mebendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Mebendazole belongs to Anti Parasitic.
Why it happens
Carbamazepine induces hepatic CYP enzymes (including CYP3A4), accelerating mebendazole metabolism.
What to do
Monitor clinical response and consider higher dosing or drug level monitoring in tissue infections. Consider an alternative anticonvulsant if treatment fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mebendazole
- Deferiprone + Mebendazole Major
- Mebendazole + Metronidazole Major
- Acalabrutinib + Mebendazole Moderate
- Ethotoin + Mebendazole Moderate
- Fosphenytoin + Mebendazole Moderate
- Mebendazole + Phenytoin Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Mebendazole?
MediHelp rates the interaction as moderate. Carbamazepine and Mebendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine can lower mebendazole concentrations, which may reduce anthelmintic effectiveness, particularly in systemic infections such as hydatid disease.
How serious is the interaction between Carbamazepine and Mebendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider higher dosing or drug level monitoring in tissue infections. Consider an alternative anticonvulsant if treatment fails.
What other medicines interact with Mebendazole?
MediHelp also lists interactions of Mebendazole with, for example, Deferiprone, Metronidazole, Acalabrutinib. The full list is on the Mebendazole page.
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