Drug interactions
Ethotoin + Midazolam
Severity: Moderate
Ethotoin and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethotoin is a hydantoin anticonvulsant with sedative effects that may add to midazolam sedation. Hydantoins can also induce metabolic enzymes, which might reduce midazolam exposure over time.
What this interaction means in plain words
Ethotoin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible CYP3A4 induction by the hydantoin class.
What to do
Monitor sedation and respiratory status, and titrate midazolam to effect. Expect that higher doses may be needed with prolonged ethotoin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Ethotoin with Midazolam?
MediHelp rates the interaction as moderate. Ethotoin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethotoin is a hydantoin anticonvulsant with sedative effects that may add to midazolam sedation. Hydantoins can also induce metabolic enzymes, which might reduce midazolam exposure over time.
How serious is the interaction between Ethotoin and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and titrate midazolam to effect. Expect that higher doses may be needed with prolonged ethotoin therapy.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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