Drug interactions
Etodolac + Gliclazide
Severity: Minor
Etodolac and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs, including etodolac, have occasionally been linked with enhanced sulfonylurea effect and hypoglycemia. The interaction is uncommon and variable.
What this interaction means in plain words
Etodolac and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etodolac belongs to Musculoskeletal; Gliclazide belongs to Endocrine.
Why it happens
Possible protein-binding displacement or metabolic competition; the mechanism is not established.
What to do
Monitor blood glucose when etodolac is started, especially in the elderly. Adjust the gliclazide dose if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etodolac and Gliclazide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gliclazide
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Gliclazide?
MediHelp rates the interaction as minor. Etodolac and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs, including etodolac, have occasionally been linked with enhanced sulfonylurea effect and hypoglycemia. The interaction is uncommon and variable.
How serious is the interaction between Etodolac and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when etodolac is started, especially in the elderly. Adjust the gliclazide dose if low readings occur.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
