Drug interactions
Etodolac + Glipizide-metformin
Severity: Moderate
Etodolac and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea hypoglycemia and impair renal function, which raises metformin accumulation risk. Effects are usually modest.
What this interaction means in plain words
Etodolac and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Glipizide-metformin belongs to Endocrine.
Why it happens
Possible protein-binding displacement and prostaglandin-mediated reduction in renal clearance.
What to do
Monitor glucose and renal function during regular NSAID use, using the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Glipizide-metformin?
MediHelp rates the interaction as moderate. Etodolac and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can potentiate sulfonylurea hypoglycemia and impair renal function, which raises metformin accumulation risk. Effects are usually modest.
How serious is the interaction between Etodolac and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function during regular NSAID use, using the lowest effective dose.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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