Drug interactions
Etodolac + Glyburide-metformin
Severity: Moderate
Etodolac and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the hypoglycemic effect of sulfonylureas, and NSAID-related renal impairment can increase metformin accumulation. The combination is usually manageable with monitoring.
What this interaction means in plain words
Etodolac and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible protein-binding displacement and prostaglandin effects; reduced renal function may impair metformin elimination.
What to do
Monitor blood glucose and renal function, and use the lowest effective etodolac dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Etodolac with Glyburide-metformin?
MediHelp rates the interaction as moderate. Etodolac and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the hypoglycemic effect of sulfonylureas, and NSAID-related renal impairment can increase metformin accumulation. The combination is usually manageable with monitoring.
How serious is the interaction between Etodolac and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and use the lowest effective etodolac dose for the shortest time.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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