Drug interactions
Etodolac + Ofloxacin
Severity: Moderate
Etodolac and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can lower the seizure threshold and NSAIDs may increase this risk. Seizures are uncommon but more likely with predisposing conditions or high doses.
What this interaction means in plain words
Etodolac and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone inhibition of GABA-A receptor binding, possibly potentiated by NSAIDs.
What to do
Avoid the combination in patients with seizure disorders and keep ofloxacin dose adjusted to renal function. Stop ofloxacin if CNS excitation or seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Etodolac with Ofloxacin?
MediHelp rates the interaction as moderate. Etodolac and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can lower the seizure threshold and NSAIDs may increase this risk. Seizures are uncommon but more likely with predisposing conditions or high doses.
How serious is the interaction between Etodolac and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders and keep ofloxacin dose adjusted to renal function. Stop ofloxacin if CNS excitation or seizures occur.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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