Drug interactions
Etodolac + Paroxetine
Severity: Moderate
Etodolac and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as paroxetine combined with NSAIDs increase the risk of gastrointestinal and other bleeding compared with either drug alone. Older patients and those with ulcer history are most at risk.
What this interaction means in plain words
Etodolac and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRI depletion of platelet serotonin impairs aggregation, adding to NSAID platelet inhibition and mucosal damage.
What to do
Consider a proton pump inhibitor for gastroprotection in at-risk patients and monitor for melena, hematemesis or anemia. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Etodolac with Paroxetine?
MediHelp rates the interaction as moderate. Etodolac and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs such as paroxetine combined with NSAIDs increase the risk of gastrointestinal and other bleeding compared with either drug alone. Older patients and those with ulcer history are most at risk.
How serious is the interaction between Etodolac and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor for gastroprotection in at-risk patients and monitor for melena, hematemesis or anemia. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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