Drug interactions
Etodolac + Spironolactone
Severity: Major
Etodolac and Spironolactone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis, which lowers renin-aldosterone and potassium excretion and blunts the diuretic and antihypertensive effect. Together with spironolactone this can cause hyperkalemia and acute kidney injury, especially in older patients or those with renal impairment.
What this interaction means in plain words
Etodolac and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Spironolactone belongs to Cardiovascular.
Why it happens
NSAID-induced reduction of renal prostaglandins and renal perfusion combined with aldosterone antagonism, reducing potassium excretion.
What to do
Monitor serum potassium and creatinine within the first week and periodically afterwards. Avoid or limit NSAID use in patients with heart failure or CKD.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Etodolac with Spironolactone?
MediHelp rates the interaction as major. Etodolac and Spironolactone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce renal prostaglandin synthesis, which lowers renin-aldosterone and potassium excretion and blunts the diuretic and antihypertensive effect. Together with spironolactone this can cause hyperkalemia and acute kidney injury, especially in older patients or those with renal impairment.
How serious is the interaction between Etodolac and Spironolactone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine within the first week and periodically afterwards. Avoid or limit NSAID use in patients with heart failure or CKD.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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