Drug interactions
Etodolac + Timolol
Severity: Moderate
Etodolac and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of beta-blockers with prolonged use. Systemic effect of ophthalmic timolol is smaller but still possible. Renal effects and fluid retention may contribute.
What this interaction means in plain words
Etodolac and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Timolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis with sodium and water retention opposes antihypertensive effect.
What to do
Monitor blood pressure when etodolac is used for more than a few days with oral timolol, and adjust antihypertensive therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Etodolac with Timolol?
MediHelp rates the interaction as moderate. Etodolac and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the blood pressure lowering effect of beta-blockers with prolonged use. Systemic effect of ophthalmic timolol is smaller but still possible. Renal effects and fluid retention may contribute.
How serious is the interaction between Etodolac and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when etodolac is used for more than a few days with oral timolol, and adjust antihypertensive therapy if control worsens.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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