Drug interactions
Etodolac + Tobramycin
Severity: Moderate
Etodolac and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may lower renal clearance of tobramycin, with raised concentrations demonstrated mainly in preterm infants. Both drugs can adversely affect the kidney, so combined use may increase nephrotoxicity risk.
What this interaction means in plain words
Etodolac and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etodolac belongs to Musculoskeletal; Tobramycin belongs to Anti Bacterial.
Why it happens
NSAID-mediated reduction in renal prostaglandins and glomerular filtration lowers aminoglycoside elimination.
What to do
Monitor tobramycin trough levels and serum creatinine, particularly in neonates and renally impaired patients. Adjust the dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Etodolac with Tobramycin?
MediHelp rates the interaction as moderate. Etodolac and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may lower renal clearance of tobramycin, with raised concentrations demonstrated mainly in preterm infants. Both drugs can adversely affect the kidney, so combined use may increase nephrotoxicity risk.
How serious is the interaction between Etodolac and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin trough levels and serum creatinine, particularly in neonates and renally impaired patients. Adjust the dose according to levels.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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