Drug interactions
Etodolac + Tolvaptan
Severity: Minor
Etodolac and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan does not raise potassium in a meaningful way, so the legacy concern is unfounded. NSAIDs may affect renal function and volume status in patients treated with tolvaptan, but there is no well-defined interaction.
What this interaction means in plain words
Etodolac and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etodolac belongs to Musculoskeletal; Tolvaptan belongs to Endocrine.
Why it happens
No established mechanism; theoretical renal hemodynamic effects of NSAIDs during aquaresis.
What to do
Monitor renal function and serum sodium as per tolvaptan labeling; no specific change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Etodolac with Tolvaptan?
MediHelp rates the interaction as minor. Etodolac and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan does not raise potassium in a meaningful way, so the legacy concern is unfounded. NSAIDs may affect renal function and volume status in patients treated with tolvaptan, but there is no well-defined interaction.
How serious is the interaction between Etodolac and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum sodium as per tolvaptan labeling; no specific change is needed.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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