Drug interactions
Etodolac + Triamterene
Severity: Major
Etodolac and Triamterene: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can cause hyperkalemia and reduce renal blood flow, and triamterene retains potassium. The combination raises risk of hyperkalemia and acute kidney injury, and the NSAID with triamterene has been associated with reduced kidney function.
What this interaction means in plain words
Etodolac and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etodolac belongs to Musculoskeletal; Triamterene belongs to Cardiovascular.
Why it happens
Additive potassium retention and NSAID-induced inhibition of renal prostaglandins.
What to do
Avoid the combination where possible; if used, monitor serum potassium and renal function closely. Ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Etodolac with Triamterene?
MediHelp rates the interaction as major. Etodolac and Triamterene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac can cause hyperkalemia and reduce renal blood flow, and triamterene retains potassium. The combination raises risk of hyperkalemia and acute kidney injury, and the NSAID with triamterene has been associated with reduced kidney function.
How serious is the interaction between Etodolac and Triamterene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and renal function closely. Ensure adequate hydration.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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