Drug interactions
Etomidate + Triprolidine
Severity: Moderate
Etomidate and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anesthetic inducing hypnosis. Prior or concurrent use of sedating triprolidine may add to sedative and depressant effects during anesthesia and recovery.
What this interaction means in plain words
Etomidate and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etomidate belongs to Central Nervous System; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depression from GABA-A potentiation and H1 receptor antagonism.
What to do
Inform the anesthesia team of recent antihistamine use and titrate anesthetic doses to effect. Monitor sedation depth and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Etomidate with Triprolidine?
MediHelp rates the interaction as moderate. Etomidate and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anesthetic inducing hypnosis. Prior or concurrent use of sedating triprolidine may add to sedative and depressant effects during anesthesia and recovery.
How serious is the interaction between Etomidate and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of recent antihistamine use and titrate anesthetic doses to effect. Monitor sedation depth and recovery.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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