Drug interactions
Etonogestrel + Fosamprenavir
Severity: Moderate
Etonogestrel and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted fosamprenavir can alter hormonal contraceptive exposure and has been associated with reduced efficacy or changes in hormone levels. The implant may be less reliable and adverse effects may change.
What this interaction means in plain words
Etonogestrel and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Modulation of CYP3A4 by amprenavir/ritonavir, altering etonogestrel metabolism.
What to do
Advise condoms in addition to the implant and consider a non-hormonal or injectable alternative if reliability is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Fosamprenavir?
MediHelp rates the interaction as moderate. Etonogestrel and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Boosted fosamprenavir can alter hormonal contraceptive exposure and has been associated with reduced efficacy or changes in hormone levels. The implant may be less reliable and adverse effects may change.
How serious is the interaction between Etonogestrel and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise condoms in addition to the implant and consider a non-hormonal or injectable alternative if reliability is a concern.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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