Drug interactions
Etonogestrel + Hydrocortisone
Severity: Minor
Etonogestrel and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is only a weak CYP3A4 inducer at usual doses, so any reduction in etonogestrel exposure is unlikely to be clinically meaningful. No loss of contraceptive efficacy is established with this combination.
What this interaction means in plain words
Etonogestrel and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etonogestrel belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone; not clinically established.
What to do
No routine action is needed; ask the patient to report breakthrough bleeding or concerns about contraceptive efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Hydrocortisone?
MediHelp rates the interaction as minor. Etonogestrel and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is only a weak CYP3A4 inducer at usual doses, so any reduction in etonogestrel exposure is unlikely to be clinically meaningful. No loss of contraceptive efficacy is established with this combination.
How serious is the interaction between Etonogestrel and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; ask the patient to report breakthrough bleeding or concerns about contraceptive efficacy.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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