Drug interactions
Etonogestrel + Indinavir
Severity: Minor
Etonogestrel and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise progestin exposure, increasing hormonal adverse effects. Contraceptive efficacy is not expected to be reduced.
What this interaction means in plain words
Etonogestrel and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 metabolism of etonogestrel.
What to do
Monitor for progestogenic adverse effects; no dose change is usually required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Indinavir?
MediHelp rates the interaction as minor. Etonogestrel and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may raise progestin exposure, increasing hormonal adverse effects. Contraceptive efficacy is not expected to be reduced.
How serious is the interaction between Etonogestrel and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects; no dose change is usually required.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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