Drug interactions
Etonogestrel + Lumefantrine
Severity: Minor
Etonogestrel and Lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine has not been clearly shown to induce CYP3A4 on its own. Any reduction in contraceptive exposure is more likely tied to artemether in the fixed combination.
What this interaction means in plain words
Etonogestrel and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mechanism is not established for lumefantrine alone.
What to do
If given as artemether/lumefantrine, use an additional barrier method during and shortly after treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etonogestrel
Frequently asked questions
Can I take Etonogestrel with Lumefantrine?
MediHelp rates the interaction as minor. Etonogestrel and Lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lumefantrine has not been clearly shown to induce CYP3A4 on its own. Any reduction in contraceptive exposure is more likely tied to artemether in the fixed combination.
How serious is the interaction between Etonogestrel and Lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If given as artemether/lumefantrine, use an additional barrier method during and shortly after treatment.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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