Drug interactions
Etoposide + Etravirine
Severity: Moderate
Etoposide and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a weak to moderate CYP3A4 inducer and may lower etoposide exposure. Reduced exposure could diminish antitumor efficacy.
What this interaction means in plain words
Etoposide and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Etravirine belongs to Anti Virals.
Why it happens
Induction of CYP3A4 increases etoposide metabolic clearance.
What to do
Monitor response to etoposide therapy and consider alternative antiretrovirals if efficacy appears compromised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etoposide with Etravirine?
MediHelp rates the interaction as moderate. Etoposide and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a weak to moderate CYP3A4 inducer and may lower etoposide exposure. Reduced exposure could diminish antitumor efficacy.
How serious is the interaction between Etoposide and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to etoposide therapy and consider alternative antiretrovirals if efficacy appears compromised.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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