Drug interactions
Etoposide + Fosaprepitant
Severity: Minor
Etoposide and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor after single-dose use, with a modest effect on etoposide exposure. Clinically significant toxicity is uncommon, since the combination is routinely used in chemotherapy regimens.
What this interaction means in plain words
Etoposide and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Weak to moderate transient CYP3A4 inhibition slightly reduces etoposide clearance.
What to do
No routine adjustment is needed; monitor blood counts as usual during etoposide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Etoposide with Fosaprepitant?
MediHelp rates the interaction as minor. Etoposide and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, converted to aprepitant, is a moderate CYP3A4 inhibitor after single-dose use, with a modest effect on etoposide exposure. Clinically significant toxicity is uncommon, since the combination is routinely used in chemotherapy regimens.
How serious is the interaction between Etoposide and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood counts as usual during etoposide therapy.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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