Drug interactions
Etoposide + Hydroxycarbamide
Severity: Moderate
Etoposide and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, so combined use may produce more profound cytopenias. This raises the risk of infection and bleeding.
What this interaction means in plain words
Etoposide and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppressive effects.
What to do
Monitor complete blood counts frequently. Reduce doses or delay cycles if significant neutropenia or thrombocytopenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Etoposide with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Etoposide and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, so combined use may produce more profound cytopenias. This raises the risk of infection and bleeding.
How serious is the interaction between Etoposide and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently. Reduce doses or delay cycles if significant neutropenia or thrombocytopenia occurs.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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