Drug interactions
Etoposide + Itraconazole
Severity: Moderate
Etoposide and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase etoposide exposure, raising the risk of myelosuppression and mucositis. Etoposide is cleared in part by CYP3A4 and handled by P-glycoprotein, both of which itraconazole inhibits.
What this interaction means in plain words
Etoposide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits P-glycoprotein and CYP3A4, reducing etoposide clearance.
What to do
Monitor blood counts closely and watch for etoposide toxicity. Consider an alternative antifungal or an etoposide dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Itraconazole?
MediHelp rates the interaction as moderate. Etoposide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase etoposide exposure, raising the risk of myelosuppression and mucositis. Etoposide is cleared in part by CYP3A4 and handled by P-glycoprotein, both of which itraconazole inhibits.
How serious is the interaction between Etoposide and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and watch for etoposide toxicity. Consider an alternative antifungal or an etoposide dose reduction if toxicity develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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