Drug interactions
Etoposide + Midazolam
Severity: Minor
Etoposide and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is a CYP3A4 substrate without clinically significant inhibitory effect on it. A relevant change in midazolam exposure is unlikely.
What this interaction means in plain words
Etoposide and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
No established mechanism; possible minor CYP3A4 substrate competition.
What to do
No adjustment needed; use standard monitoring of sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Etoposide with Midazolam?
MediHelp rates the interaction as minor. Etoposide and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etoposide is a CYP3A4 substrate without clinically significant inhibitory effect on it. A relevant change in midazolam exposure is unlikely.
How serious is the interaction between Etoposide and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; use standard monitoring of sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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