Drug interactions
Etoposide + Ribociclib
Severity: Moderate
Etoposide and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise etoposide exposure, since etoposide is partly cleared through CYP3A4. Higher exposure could increase myelosuppression and mucositis.
What this interaction means in plain words
Etoposide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4-mediated metabolism of etoposide, reducing its clearance.
What to do
Monitor blood counts closely during the combination and consider reducing the etoposide dose if marked myelosuppression or mucositis develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Etoposide with Ribociclib?
MediHelp rates the interaction as moderate. Etoposide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise etoposide exposure, since etoposide is partly cleared through CYP3A4. Higher exposure could increase myelosuppression and mucositis.
How serious is the interaction between Etoposide and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely during the combination and consider reducing the etoposide dose if marked myelosuppression or mucositis develops.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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