Drug interactions
Etoposide + Tacrolimus
Severity: Moderate
Etoposide and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus inhibits P-glycoprotein, which is involved in etoposide efflux and elimination, so etoposide exposure may rise. This could enhance myelosuppression and gastrointestinal toxicity, and both drugs may add to immunosuppression.
What this interaction means in plain words
Etoposide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus inhibits P-glycoprotein-mediated efflux of etoposide, and the two drugs have additive immunosuppressive effects.
What to do
Monitor complete blood counts and signs of infection, and reduce the etoposide dose if severe toxicity occurs. Check tacrolimus trough levels as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Etoposide with Tacrolimus?
MediHelp rates the interaction as moderate. Etoposide and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus inhibits P-glycoprotein, which is involved in etoposide efflux and elimination, so etoposide exposure may rise. This could enhance myelosuppression and gastrointestinal toxicity, and both drugs may add to immunosuppression.
How serious is the interaction between Etoposide and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection, and reduce the etoposide dose if severe toxicity occurs. Check tacrolimus trough levels as clinically indicated.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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