Drug interactions
Etoposide + Tazemetostat
Severity: Minor
Etoposide and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and could slightly lower etoposide exposure. Etoposide is not expected to meaningfully change tazemetostat exposure.
What this interaction means in plain words
Etoposide and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etoposide belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may increase etoposide metabolism.
What to do
No dose change is routinely needed. Monitor treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Etoposide with Tazemetostat?
MediHelp rates the interaction as minor. Etoposide and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and could slightly lower etoposide exposure. Etoposide is not expected to meaningfully change tazemetostat exposure.
How serious is the interaction between Etoposide and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor treatment response.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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