Drug interactions
Etoposide + Trastuzumab deruxtecan
Severity: Moderate
Etoposide and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause myelosuppression, so together they may increase neutropenia and infection risk. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
What this interaction means in plain words
Etoposide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppression from the topoisomerase I inhibitor payload and etoposide.
What to do
Monitor blood counts regularly and for infection and respiratory symptoms. Adjust doses or delay cycles for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Etoposide with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Etoposide and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause myelosuppression, so together they may increase neutropenia and infection risk. Trastuzumab deruxtecan also carries a risk of interstitial lung disease.
How serious is the interaction between Etoposide and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and for infection and respiratory symptoms. Adjust doses or delay cycles for severe neutropenia.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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