Drug interactions
Etoposide + Vemurafenib
Severity: Moderate
Etoposide and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib may inhibit P-glycoprotein and raise etoposide exposure, possibly increasing toxicity.
What this interaction means in plain words
Etoposide and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etoposide belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp efflux of etoposide.
What to do
Monitor blood counts and etoposide toxicity. Reduce the etoposide dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Etoposide with Vemurafenib?
MediHelp rates the interaction as moderate. Etoposide and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib may inhibit P-glycoprotein and raise etoposide exposure, possibly increasing toxicity.
How serious is the interaction between Etoposide and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and etoposide toxicity. Reduce the etoposide dose if toxicity develops.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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