Drug interactions
Etrasimod + Imatinib
Severity: Moderate
Etrasimod and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes by sequestering them in lymphoid tissue, and imatinib can cause myelosuppression. Combined use may add to immunosuppression and infection risk, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Imatinib belongs to Oncology.
Why it happens
Additive immunosuppressive and lymphocyte-lowering pharmacodynamic effects.
What to do
Avoid combining when alternatives exist; if used together, monitor blood counts including lymphocytes and watch closely for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Imatinib?
MediHelp rates the interaction as moderate. Etrasimod and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod reduces circulating lymphocytes by sequestering them in lymphoid tissue, and imatinib can cause myelosuppression. Combined use may add to immunosuppression and infection risk, and the combination has not been studied.
How serious is the interaction between Etrasimod and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when alternatives exist; if used together, monitor blood counts including lymphocytes and watch closely for infection.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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