Drug interactions
Etrasimod + Irbesartan
Severity: Minor
Etrasimod and Irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod exposure increases with CYP2C8 inhibitors in CYP2C9 poor metabolizers. Irbesartan is not a meaningful CYP2C8 inhibitor, so a relevant interaction is unlikely.
What this interaction means in plain words
Etrasimod and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etrasimod belongs to Gastrointestinal Tract; Irbesartan belongs to Cardiovascular.
Why it happens
No established mechanism; irbesartan is not a clinically relevant CYP2C8 inhibitor.
What to do
No adjustment needed; monitor heart rate per routine etrasimod care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Irbesartan?
MediHelp rates the interaction as minor. Etrasimod and Irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod exposure increases with CYP2C8 inhibitors in CYP2C9 poor metabolizers. Irbesartan is not a meaningful CYP2C8 inhibitor, so a relevant interaction is unlikely.
How serious is the interaction between Etrasimod and Irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor heart rate per routine etrasimod care.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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