Drug interactions
Etrasimod + Lapatinib
Severity: Moderate
Etrasimod and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP2C8, and etrasimod exposure may increase, especially in CYP2C9 poor metabolizers. Etrasimod's immunomodulating effect may also add to the immunosuppression of antineoplastic therapy, raising infection risk.
What this interaction means in plain words
Etrasimod and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Lapatinib belongs to Oncology.
Why it happens
CYP2C8 inhibition by lapatinib reduces etrasimod clearance, with possible additive immune effects.
What to do
Avoid use in known CYP2C9 poor metabolizers. Otherwise monitor for infection, heart rate and other etrasimod adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Etrasimod and Lapatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Lapatinib?
MediHelp rates the interaction as moderate. Etrasimod and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib inhibits CYP2C8, and etrasimod exposure may increase, especially in CYP2C9 poor metabolizers. Etrasimod's immunomodulating effect may also add to the immunosuppression of antineoplastic therapy, raising infection risk.
How serious is the interaction between Etrasimod and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use in known CYP2C9 poor metabolizers. Otherwise monitor for infection, heart rate and other etrasimod adverse effects.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
