Drug interactions
Etrasimod + Mifepristone
Severity: Moderate
Etrasimod and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod is cleared by several enzymes including CYP2C8, CYP2C9 and CYP3A4. Inhibition of more than one of these pathways, particularly in CYP2C9 poor metabolizers, may raise etrasimod exposure and increase adverse effects such as bradyarrhythmia and infection risk.
What this interaction means in plain words
Etrasimod and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 and may reduce multiple metabolic pathways of etrasimod, increasing its exposure.
What to do
Avoid use in patients known to be CYP2C9 poor metabolizers. Otherwise monitor heart rate and for adverse effects of etrasimod.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Mifepristone?
MediHelp rates the interaction as moderate. Etrasimod and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod is cleared by several enzymes including CYP2C8, CYP2C9 and CYP3A4. Inhibition of more than one of these pathways, particularly in CYP2C9 poor metabolizers, may raise etrasimod exposure and increase adverse effects such as bradyarrhythmia and infection risk.
How serious is the interaction between Etrasimod and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use in patients known to be CYP2C9 poor metabolizers. Otherwise monitor heart rate and for adverse effects of etrasimod.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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