Drug interactions
Etrasimod + Mitoxantrone
Severity: Major
Etrasimod and Mitoxantrone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and mitoxantrone is immunosuppressive and myelosuppressive. Together they may increase the risk of serious infection, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Mitoxantrone belongs to Central Nervous System.
Why it happens
Additive immunosuppression from S1P receptor modulation plus cytotoxic marrow suppression.
What to do
Avoid co-administration where possible, and allow washout of etrasimod after stopping. Monitor lymphocyte and neutrophil counts and for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitoxantrone
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Mitoxantrone?
MediHelp rates the interaction as major. Etrasimod and Mitoxantrone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes, and mitoxantrone is immunosuppressive and myelosuppressive. Together they may increase the risk of serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Mitoxantrone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-administration where possible, and allow washout of etrasimod after stopping. Monitor lymphocyte and neutrophil counts and for infection.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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