Drug interactions
Etrasimod + Nadolol
Severity: Moderate
Etrasimod and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently reduce heart rate and slow AV conduction when started. Combined with nadolol, additive bradycardia or conduction delay is possible, particularly if a beta blocker is started after etrasimod.
What this interaction means in plain words
Etrasimod and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Nadolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects from S1P receptor modulation and beta blockade.
What to do
Review cardiac history and ECG before starting etrasimod in patients on nadolol, and monitor heart rate. Seek cardiology input in patients with conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Nadolol?
MediHelp rates the interaction as moderate. Etrasimod and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently reduce heart rate and slow AV conduction when started. Combined with nadolol, additive bradycardia or conduction delay is possible, particularly if a beta blocker is started after etrasimod.
How serious is the interaction between Etrasimod and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review cardiac history and ECG before starting etrasimod in patients on nadolol, and monitor heart rate. Seek cardiology input in patients with conduction disease.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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