Drug interactions
Etrasimod + Nebivolol
Severity: Moderate
Etrasimod and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can transiently slow heart rate and delay AV conduction on initiation, and beta-blockers have similar effects. Starting a beta-blocker in a patient on stable etrasimod, or the reverse in some patients, may produce additive bradycardia.
What this interaction means in plain words
Etrasimod and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Nebivolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects via S1P receptor modulation and beta-blockade.
What to do
Monitor heart rate and ECG when starting either drug alongside the other. Seek cardiology advice if there are conduction abnormalities or symptomatic bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Nebivolol?
MediHelp rates the interaction as moderate. Etrasimod and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can transiently slow heart rate and delay AV conduction on initiation, and beta-blockers have similar effects. Starting a beta-blocker in a patient on stable etrasimod, or the reverse in some patients, may produce additive bradycardia.
How serious is the interaction between Etrasimod and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG when starting either drug alongside the other. Seek cardiology advice if there are conduction abnormalities or symptomatic bradycardia.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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