Drug interactions
Etrasimod + Nicardipine
Severity: Minor
Etrasimod and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient bradycardia and AV conduction delay at initiation. Nicardipine is a dihydropyridine with little direct nodal effect, so a significant additive effect is unlikely, though reflex responses and hypotension may complicate assessment.
What this interaction means in plain words
Etrasimod and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etrasimod belongs to Gastrointestinal Tract; Nicardipine belongs to Cardiovascular.
Why it happens
Etrasimod's sphingosine-1-phosphate receptor effects on heart rate may add to hemodynamic changes from nicardipine.
What to do
Follow standard etrasimod initiation monitoring, including heart rate and blood pressure, in patients on nicardipine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Nicardipine?
MediHelp rates the interaction as minor. Etrasimod and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etrasimod can cause transient bradycardia and AV conduction delay at initiation. Nicardipine is a dihydropyridine with little direct nodal effect, so a significant additive effect is unlikely, though reflex responses and hypotension may complicate assessment.
How serious is the interaction between Etrasimod and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow standard etrasimod initiation monitoring, including heart rate and blood pressure, in patients on nicardipine.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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