Drug interactions
Etrasimod + Obinutuzumab
Severity: Major
Etrasimod and Obinutuzumab: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab depletes B cells and etrasimod reduces circulating lymphocytes, so together they may substantially raise infection risk. This combination has not been studied. Etrasimod's effect on lymphocyte counts can persist for some weeks after discontinuation.
What this interaction means in plain words
Etrasimod and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Obinutuzumab belongs to Oncology.
Why it happens
Additive immunosuppression from anti-CD20 B-cell depletion and S1P receptor modulator lymphocyte sequestration.
What to do
Avoid concurrent use. If sequential use is needed, allow for the persistent effects of obinutuzumab and etrasimod and monitor for infection and lymphocyte counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Obinutuzumab
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Obinutuzumab?
MediHelp rates the interaction as major. Etrasimod and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Obinutuzumab depletes B cells and etrasimod reduces circulating lymphocytes, so together they may substantially raise infection risk. This combination has not been studied. Etrasimod's effect on lymphocyte counts can persist for some weeks after discontinuation.
How serious is the interaction between Etrasimod and Obinutuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. If sequential use is needed, allow for the persistent effects of obinutuzumab and etrasimod and monitor for infection and lymphocyte counts.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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