Drug interactions
Etrasimod + Paclitaxel
Severity: Major
Etrasimod and Paclitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes, and paclitaxel is myelosuppressive, so combined use may add to immunosuppression and infection risk. The combination has not been formally studied.
What this interaction means in plain words
Etrasimod and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Paclitaxel belongs to Oncology.
Why it happens
Additive immunosuppression from S1P receptor modulation and cytotoxic myelosuppression.
What to do
Avoid concurrent use where possible and monitor blood counts and for signs of infection if unavoidable. Allow for lymphocyte recovery after stopping etrasimod.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paclitaxel
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Paclitaxel?
MediHelp rates the interaction as major. Etrasimod and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes, and paclitaxel is myelosuppressive, so combined use may add to immunosuppression and infection risk. The combination has not been formally studied.
How serious is the interaction between Etrasimod and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and monitor blood counts and for signs of infection if unavoidable. Allow for lymphocyte recovery after stopping etrasimod.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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