Drug interactions
Etrasimod + Procarbazine
Severity: Major
Etrasimod and Procarbazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes, and procarbazine is myelosuppressive and immunosuppressive. Together they may increase the risk of serious infection, and the combination has not been studied.
What this interaction means in plain words
Etrasimod and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Procarbazine belongs to Oncology.
Why it happens
Additive immunosuppression through S1P receptor-mediated lymphocyte sequestration and chemotherapy-induced myelosuppression.
What to do
Avoid coadministration during and for several weeks after etrasimod. If used together, monitor blood counts and watch for infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Procarbazine?
MediHelp rates the interaction as major. Etrasimod and Procarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes, and procarbazine is myelosuppressive and immunosuppressive. Together they may increase the risk of serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Procarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration during and for several weeks after etrasimod. If used together, monitor blood counts and watch for infection.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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