Drug interactions
Etrasimod + Quetiapine
Severity: Moderate
Etrasimod and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can slow heart rate and delay AV conduction when started, and quetiapine can prolong the QT interval. The combination may raise the risk of arrhythmia such as torsades de pointes, particularly with bradycardia.
What this interaction means in plain words
Etrasimod and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Quetiapine belongs to Central Nervous System.
Why it happens
Additive effects of S1P receptor modulator-induced bradycardia and quetiapine-related QT prolongation.
What to do
Obtain a baseline ECG before starting etrasimod and seek cardiology advice if the patient is on QT-prolonging drugs. Correct potassium and magnesium and monitor heart rate and ECG during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Quetiapine?
MediHelp rates the interaction as moderate. Etrasimod and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod can slow heart rate and delay AV conduction when started, and quetiapine can prolong the QT interval. The combination may raise the risk of arrhythmia such as torsades de pointes, particularly with bradycardia.
How serious is the interaction between Etrasimod and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting etrasimod and seek cardiology advice if the patient is on QT-prolonging drugs. Correct potassium and magnesium and monitor heart rate and ECG during initiation.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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