Drug interactions
Etrasimod + Regorafenib
Severity: Moderate
Etrasimod and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes and regorafenib is an antineoplastic with potential myelosuppressive and infection-related effects. Together they may increase infection risk, though combined use has not been formally studied.
What this interaction means in plain words
Etrasimod and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Regorafenib belongs to Oncology.
Why it happens
Additive immunosuppression from S1P receptor modulation-related lymphocyte sequestration and antineoplastic effects.
What to do
Monitor for signs of infection and check blood counts. Consider whether etrasimod is needed during cancer therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Regorafenib?
MediHelp rates the interaction as moderate. Etrasimod and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod reduces circulating lymphocytes and regorafenib is an antineoplastic with potential myelosuppressive and infection-related effects. Together they may increase infection risk, though combined use has not been formally studied.
How serious is the interaction between Etrasimod and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts. Consider whether etrasimod is needed during cancer therapy.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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