Drug interactions
Etrasimod + Rifampicin
Severity: Major
Etrasimod and Rifampicin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin reduces etrasimod exposure and may lead to loss of efficacy in ulcerative colitis.
What this interaction means in plain words
Etrasimod and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces CYP2C8, CYP2C9 and CYP3A4, increasing etrasimod clearance.
What to do
Avoid coadministration. Use an alternative antimicrobial if possible, and monitor disease control if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Etrasimod with Rifampicin?
MediHelp rates the interaction as major. Etrasimod and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin reduces etrasimod exposure and may lead to loss of efficacy in ulcerative colitis.
How serious is the interaction between Etrasimod and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative antimicrobial if possible, and monitor disease control if the combination cannot be avoided.
What other medicines interact with Etrasimod?
MediHelp also lists interactions of Etrasimod with, for example, Abatacept, Amiodarone, Anagrelide. The full list is on the Etrasimod page.
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