Drug interactions
Etrasimod + Vardenafil
Severity: Moderate
Etrasimod and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil can prolong the QT interval, and etrasimod can slow heart rate and AV conduction at initiation. Together they may add to the risk of arrhythmia, though direct evidence for this pair is limited.
What this interaction means in plain words
Etrasimod and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etrasimod belongs to Gastrointestinal Tract; Vardenafil belongs to Genitourinary.
Why it happens
Additive effects on QT interval (vardenafil) and heart rate and conduction (etrasimod).
What to do
Review ECG and cardiac history before starting etrasimod and monitor heart rate and rhythm at initiation. Avoid in patients with QT prolongation or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Vardenafil?
MediHelp rates the interaction as moderate. Etrasimod and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil can prolong the QT interval, and etrasimod can slow heart rate and AV conduction at initiation. Together they may add to the risk of arrhythmia, though direct evidence for this pair is limited.
How serious is the interaction between Etrasimod and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review ECG and cardiac history before starting etrasimod and monitor heart rate and rhythm at initiation. Avoid in patients with QT prolongation or other risk factors.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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