Drug interactions
Etrasimod + Verapamil
Severity: Major
Etrasimod and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient heart rate slowing and AV conduction delay when started, and verapamil has similar effects. Combined use may produce additive bradycardia or heart block.
What this interaction means in plain words
Etrasimod and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Verapamil belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic suppression of sinus node and AV nodal conduction.
What to do
Obtain a baseline ECG and seek cardiology advice before starting etrasimod in patients on verapamil. Monitor heart rate and conduction after initiation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Verapamil?
MediHelp rates the interaction as major. Etrasimod and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod can cause transient heart rate slowing and AV conduction delay when started, and verapamil has similar effects. Combined use may produce additive bradycardia or heart block.
How serious is the interaction between Etrasimod and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and seek cardiology advice before starting etrasimod in patients on verapamil. Monitor heart rate and conduction after initiation.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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