Drug interactions
Etrasimod + Vinblastine
Severity: Major
Etrasimod and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes and vinblastine is myelosuppressive, so combined use may increase the risk of infection. The combination has not been studied.
What this interaction means in plain words
Etrasimod and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Vinblastine belongs to Oncology.
Why it happens
Additive immunosuppression from lymphocyte sequestration (etrasimod) and bone marrow suppression (vinblastine).
What to do
Avoid the combination where possible. If used, monitor blood counts and watch closely for infection, including for several weeks after etrasimod is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Vinblastine?
MediHelp rates the interaction as major. Etrasimod and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes and vinblastine is myelosuppressive, so combined use may increase the risk of infection. The combination has not been studied.
How serious is the interaction between Etrasimod and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor blood counts and watch closely for infection, including for several weeks after etrasimod is stopped.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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