Drug interactions
Etrasimod + Ziprasidone
Severity: Major
Etrasimod and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod can cause transient bradycardia and AV conduction delay at initiation. Ziprasidone prolongs the QT interval, and bradycardia increases the risk of torsades de pointes.
What this interaction means in plain words
Etrasimod and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive effects on heart rate and QT interval.
What to do
Avoid starting etrasimod in patients taking ziprasidone unless cardiology advises. If used, obtain a baseline ECG and monitor heart rate and rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Ziprasidone?
MediHelp rates the interaction as major. Etrasimod and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod can cause transient bradycardia and AV conduction delay at initiation. Ziprasidone prolongs the QT interval, and bradycardia increases the risk of torsades de pointes.
How serious is the interaction between Etrasimod and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting etrasimod in patients taking ziprasidone unless cardiology advises. If used, obtain a baseline ECG and monitor heart rate and rhythm.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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