Drug interactions
Etravirine + Glimepiride-pioglitazone
Severity: Minor
Etravirine and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a modest inducer of CYP3A4 and may lower pioglitazone exposure, since pioglitazone is metabolized mainly by CYP2C8 with some CYP3A4 contribution. The effect on glycemic control is expected to be small.
What this interaction means in plain words
Etravirine and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Etravirine belongs to Anti Virals; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Etravirine induces CYP3A4 (and CYP2C9/2C19 effects), potentially increasing pioglitazone clearance.
What to do
Monitor glucose control and HbA1c after starting etravirine. Adjust the pioglitazone dose if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Etravirine and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Etravirine is a modest inducer of CYP3A4 and may lower pioglitazone exposure, since pioglitazone is metabolized mainly by CYP2C8 with some CYP3A4 contribution. The effect on glycemic control is expected to be small.
How serious is the interaction between Etravirine and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control and HbA1c after starting etravirine. Adjust the pioglitazone dose if control deteriorates.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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