Drug interactions
Etravirine + Griseofulvin
Severity: Moderate
Etravirine and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 substrate, and griseofulvin may lower its concentrations through enzyme induction. Reduced exposure may risk virologic failure and resistance.
What this interaction means in plain words
Etravirine and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Griseofulvin belongs to Anti Fungals.
Why it happens
CYP3A4 induction by griseofulvin increases etravirine metabolism.
What to do
Monitor HIV viral load and consider an alternative antifungal if the combination cannot be avoided.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Griseofulvin?
MediHelp rates the interaction as moderate. Etravirine and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 substrate, and griseofulvin may lower its concentrations through enzyme induction. Reduced exposure may risk virologic failure and resistance.
How serious is the interaction between Etravirine and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider an alternative antifungal if the combination cannot be avoided.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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