Drug interactions
Etravirine + Hydrocortisone
Severity: Moderate
Etravirine and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower hydrocortisone exposure, possibly reducing its effect. This is most relevant in adrenal insufficiency, where under-replacement could be harmful.
What this interaction means in plain words
Etravirine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Etravirine belongs to Anti Virals; Hydrocortisone belongs to Endocrine.
Why it happens
Etravirine induces CYP3A4, increasing hydrocortisone metabolism.
What to do
Monitor clinical response and consider a higher hydrocortisone dose in patients on replacement therapy. Reassess when etravirine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Etravirine with Hydrocortisone?
MediHelp rates the interaction as moderate. Etravirine and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower hydrocortisone exposure, possibly reducing its effect. This is most relevant in adrenal insufficiency, where under-replacement could be harmful.
How serious is the interaction between Etravirine and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider a higher hydrocortisone dose in patients on replacement therapy. Reassess when etravirine is stopped.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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